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1 Function of Synaptic Vesicle Proteins Function Generation of electrochemical gradient of protons Transmitter uptake into vesicle Component of SNARE complex; acts in a late, essential step in vesicle fusion Ca2 binding; possible trigger for fusion and component of vesicle docking at release sites via interactions with SNARE complex and lipid; promotes clathrin-mediated endocytosis by binding AP-2 complex Possible role in regulating vesicle targeting and availability Likely to tether vesicle to actin cytoskeleton Promotes reliable coupling of action potential to exocytosis Unknown Unknown Protein Proton pump Vesicular transmitter transporter VAMPsynaptobrevin Synaptotagmin Rab3 Synapsin Cysteine string protein SV2 Synaptophysin Arg271-Thr272 liberates the N-terminal fragment 1·2, which retains the phospholipid binding characteristics of prothrombin, plus fully mature a-thrombin.
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