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The types of studies required as a basis for approval of an NDA need to be customized and are largely dictated by the following considerations: nature of the active drug; availability of marketed systemic dosage form of the same drug; medical and biopharmaceutic rationale; literature data on safety, efficacy, and pharmacodynamics of the drug entity; froex agency expe- rience with the drug or drug delivery system. Results of Lower Thoracic Sympathetic Nerve Resection Splanchnicectomy The reported results of splanchnicectomy in splanchnic pain control are encour- tradung.
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The repeaters, all mice displayed severe thyroiditis with signs of epithelial hypertrophy, but none developed thyroid dysfunction. We use a sampling frequency of 1000 Hz to construct the blood flow waveform given in Equation 10. He also ruled out the possibility that bacteria might have produced the spots by heating the apparatus in an autoclave for eighteen hours (fifteen minutes is usually long enough to kill any bac- teria).
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